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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Beta-Elemene, Fluorouracil
Phytochemical Name Beta-Elemene (PubChem CID: 6918391 )
Anticancer drug Name Fluorouracil (PubChem CID: 3385 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 236
Ref_1
Pair Name Beta-Elemene, Fluorouracil
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Gene Regulation Down-regulation Expression IKBKB hsa3551
Down-regulation Expression CHUK hsa1147
Down-regulation Expression RELA hsa5970
Down-regulation Expression CD40 hsa958
Down-regulation Expression PIK3CA hsa5290
Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Expression PIK3R1 hsa5295
Down-regulation Phosphorylation PDK1 hsa5163
Down-regulation Expression PIK3CA hsa5290
Down-regulation Phosphorylation RAF1 hsa5894
Down-regulation Phosphorylation MAPK1 hsa5594
In Vitro Model MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
BT-549 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_1092
In Vivo Model MDA-MB-231 cells (5×10⁶ cells in 100 µL of PBS) were subcutaneously injected to the left flank of each mouse.
Result The conclusion obtained, considering that the results suggest that the combination may be important specifically in the treatment of TNBC.
03. Reference
No. Title Href
1 β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways. Onco Targets Ther. 2020 Jun 9;13:5207-5222. doi: 10.2147/OTT.S242820. Click
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